Journal: Antioxidants
Article Title: Thioredoxin Downregulation Enhances Sorafenib Effects in Hepatocarcinoma Cells
doi: 10.3390/antiox8100501
Figure Lengend Snippet: Systems Biology analysis of differential proteomic data from three HCC cell lines. Quantitative data on protein levels in SNU423 and SNU475 cells relative to the levels in HepG2, the more differentiated cell line, were analyzed. Up- and down-regulated proteins were analyzed using the IPA software in terms of ( A ) canonical pathways based on the content of the Ingenuity Knowledge Base, and ( B ) Upstream Regulator Analysis to identify the cascade of upstream transcriptional regulators (see M&M for more details). The degree of activation is represented in a color scale as indicated. Red brackets have been added to highlight significant data commented on in the main text.
Article Snippet: The differentially expressed proteins together with the fold change values were analyzed with the online IPA software package (Qiagen, version 48207413) and the open software DAVID [ ].
Techniques: Software, Activation Assay